Phelsuma grandis is a diurnal arboreal species of day gecko. These geckos are part of the Phelsuma group, which consists of in excess of 70 species and subspecies. They are commonly referred to as the Madagascar giant day gecko, due to their large size. They are native to areas of tropical and subtropical forest in northern Madagascar, but have been introduced to several other subtropical locations outside their range. P. grandis feeds on various invertebrates, very small vertebrates, and nectars. It is bred and sold as an exotic pet.
Its generic name is a Latinized version of the last name of Dutch physician Murk van Phelsum. Its specific name grandis is Latin for "great". The species Phelsuma grandis described by Gray 1870 was elevated from subspecies status (P. madagascariensis grandis) by Raxworthy et al. in 2007, after environmental niche modeling revealed significant and reliable differences between it and other members of the P. madagascariensis-clade.